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Cerebral cortical thickness and gyrification changes in first-episode psychoses and multi-episode schizophrenia

A. Del Casale, M. C. Rossi-Espagnet, A. Napolitano, M. Lucignani, L. Bonanni, G. D. Kotzalidis, A. Buscajoni, L. Manelfi, V. Perrone, I. Gualtieri, R. Brugnoli, E. De Pisa, P. Girardi, A. Romano, S. Ferracuti, A. Bozzao, M. Pompili


Cortical thickness (CT) and local gyrification index (LGI) in psychotic disorders may show modifications that relate to clinical course. This observational study aimed to analyse such variables in patients with schizophrenia, compared to healthy controls (HCs). We compared CT and LGI of 18 patients with first-episode psychosis with that of 21 with multi-episode schizophrenia and 16 HCs. CT corrected for false-positive cases (Family-Wise Error Rate) showed a reduction in the multi-episode group compared to HCs in left temporal and parietal, and right temporal, parietal, occipital, and hippocampal cortices. Family-wise corrected LGI was increased in the left inferior and middle frontal cortices, and in the right fusiform gyrus, cingulate, lingual, and parahippocampal gyri in first onset patients compared to HCs. Increased LGI was absent from later stages of psychosis, suggesting that specific CT and LGI alterations may underlie different stages of illness.


Schizophrenia; First-Episode Psychoses; Multi-episode Schizophrenia; Cortical Thickness; Gyrification Index

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Alemán-Gómez Y., Janssen J., Schnack H., Balaban E., Pina-Camacho L., Alfaro-Almagro F., Castro-Fornieles J., Otero S., Baeza I., Moreno D., Bargalló N., Parellada M., Arango C., Desco M. The human cerebral cortex flattens during adolescence. J. Neurosci., 33: 15004–15010, 2013.

American Psychiatric Association. Diagnostic and statistical manual of mental disorders: DSM-IV-TR. 2000, Washington, DC: American Psychiatric Association.

Arnold S.E., Talbot K., Hahn C.G. Neurodevelopment, neuroplasticity, and new genes for schizophrenia. Prog. Brain Res., 147: 319–345, 2005.

Asmal L., du Plessis S., Vink M., Chiliza B., Kilian S., Emsley R. Symptom attribution and frontal cortical thickness in first-episode schizophrenia. Early Interv. Psychiatry, 12: 652–659, 2018.

Bartholomeusz C.F., Whittle S.L., Montague A., Ansell B., McGorry P.D., Velakoulis D., Pantelis C., Wood S.J. Sulcogyral patterns and morphological abnormalities of the orbitofrontal cortex in psychosis. Prog. Neuropsychopharmacol. Biol. Psychiatry, 44: 168–177, 2013.

Behdinan T., Foussias G., Wheeler A.L., Stefanik L., Felsky D., Remington G., Rajji T.K., Chakravarty M.M., Voineskos A.N. Neuroimaging predictors of functional outcomes in schizophrenia at baseline and 6-month follow-up. Schizophr. Res., 169: 69–75, 2015.

Bodnar M., Hovington C.L., Buchy L., Malla A.K., Joober R., Lepage M. Cortical thinning in temporo-parietal junction (TPJ) in non-affective first-episode of psychosis patients with persistent negative symptoms. PLoS One, 9: e101372, 2014.

Breier A., Buchanan R.W., Elkashef A., Munson R.C., Kirkpatrick B., Gellad F. Brain morphology and schizophrenia. A magnetic resonance imaging study of limbic, prefrontal cortex, and caudate structures. Arch. Gen. Psychiatry, 49: 921–926, 1992.

Buchy L., Ad-Dab'bagh Y., Malla A., Lepage C., Bodnar M., Joober R., Sergerie K., Evans A., Lepage M. Cortical thickness is associated with poor insight in first-episode psychosis. J Psychiatr. Res., 45: 781–787, 2011.

Buchy L., Ad-Dab'bagh Y., Lepage C., Malla A., Joober R., Evans A., Lepage M. Symptom attribution in first episode psychosis: a cortical thickness study. Psychiatry Res., 203: 6–13, 2012.

Buchy L., Makowski C., Malla A., Joober R., Lepage M. Longitudinal trajectory of clinical insight and covariation with cortical thickness in first-episode psychosis. J. Psychiatr. Res., 86: 46–54, 2017.

Buchy L., Makowski C., Malla A., Joober R., Lepage M. A longitudinal study of cognitive insight and cortical thickness in first-episode psychosis. Schizophr. Res., 193: 251–260, 2018.

Cachia A., Paillère-Martinot M.L., Galinowski A., Januel D., de Beaurepaire R., Bellivier F., Artiges E., Andoh J., Bartrés-Faz D., Duchesnay E., Rivière D., Plaze M., Mangin J.F., Martinot J.L. Cortical folding abnormalities in schizophrenia patients with resistant auditory hallucinations. Neuroimage, 39: 927–935, 2008.

Chua S.E., Cheung C., Cheung V., Tsang J.T., Chen E.Y., Wong J.C., Cheung J.P., Yip L., Tai K.S., Suckling J., McAlonan, G.M. Cerebral grey, white matter and csf in never-medicated, first-episode schizophrenia. Schizophr. Res., 89: 12–21, 2007.

Chung Y.S., Hyatt C.J., Stevens M.C. Adolescent maturation of the relationship between cortical gyrification and cognitive ability. Neuroimage, 158: 319–331, 2017.

Ciufolini S., Ponteduro M.F., Reis-Marques T., Taylor H., Mondelli V., Pariante C.M., Bonaccorso S., Chan R., Simmons A., David A., Di Forti M., Murray R.M., Dazzan P. Cortical thickness correlates of minor neurological signs in patients with first episode psychosis. Schizophr. Res., 200: 104–111, 2018.

Diederen K.M., Neggers S.F., Daalman K., Blom J.D., Goekoop R., Kahn R.S., Sommer I.E. Deactivation of the parahippocampal gyrus preceding auditory hallucinations in schizophrenia. Am. J. Psychiatry, 167: 427–435, 2010.

Dukart J., Smieskova R., Harrisberger F., Lenz C., Schmidt A., Walter A., Huber C., Riecher-Rössler A., Simon A., Lang U.E., Fusar-Poli P., Borgwardt S. Age-related brain structural alterations as an intermediate phenotype of psychosis. J. Psychiatry Neurosci., 42: 307–319, 2017.

Emami S., Guimond S., Mallar Chakravarty M., Lepage M. Cortical thickness and low insight into symptoms in enduring schizophrenia. Schizophr. Res., 170: 66–72, 2016.

Epstein K.A., Kumra S. Altered cortical maturation in adolescent cannabis users with and without schizophrenia. Schizophr. Res. 162: 143–152, 2015.

Ferro A., Roiz-Santiáñez R., Ortíz-García de la Foz V., Tordesillas-Gutiérrez D., Ayesa-Arriola R., de La Fuente-González N., Fañanás L., Brambilla P., Crespo-Facorro B. A cross-sectional and longitudinal structural magnetic resonance imaging study of the post-central gyrus in first-episode schizophrenia patients. Psychiatry Res., 231: 42–49, 2015.

Fischl B., Dale A.M. Measuring the thickness of the human cerebral cortex from magnetic resonance images. Proc. Natl. Acad. Sci. U. S. A., 97: 11050–11055, 2000.

Fujito R., Minese M., Hatada S., Kamimura N., Morinobu S., Lang D.J., Honer W.G., Sawada K. Musical deficits and cortical thickness in people with schizophrenia. Schizophr. Res., 197: 233-239, 2018.

Gilmore J.H., Knickmeyer R.C., Gao W. Imaging structural and functional brain development in early childhood. Nat. Rev. Neurosci., 19: 123-137, 2018.

Glahn D.C., Laird A.R., Ellison-Wright I., Thelen S.M., Robinson J.L., Lancaster J.L., Bullmore E., Fox P.T. Meta-analysis of gray matter anomalies in schizophrenia: application of anatomic likelihood estimation and network analysis. Biol. Psychiatry, 64: 774–781, 2008.

Godwin D., Alpert K.I., Wang L., Mamah D. Regional cortical thinning in young adults with schizophrenia but not psychotic or non-psychotic bipolar I disorder. Int. J. Bipolar Disord., 6: 16, 2018.

Gong Q., Lui S., Sweeney J.A. A selective review of cerebral abnormalities in patients with first-episode schizophrenia before and after treatment. Am. J. Psychiatry, 173: 232–243, 2016.

Gregory M.D., Kippenhan J.S., Dickinson D., Carrasco J., Mattay V.S., Weinberger D.R., Berman K.F. Regional variations in brain gyrification are associated with general cognitive ability in humans. Curr. Biol., 26: 1301-1305, 2016.

Guma E., Devenyi G.A., Malla A., Shah J., Chakravarty M.M., Pruessner M. Neuroanatomical and symptomatic sex differences in individuals at clinical high risk for psychosis. Front. Psychiatry, 8: 291, 2017.

Guo S., Palaniyappan L., Liddle P.F., Feng J. Dynamic cerebral reorganization in the pathophysiology of schizophrenia: a MRI-derived cortical thickness study. Psychol. Med., 46: 2201-2214, 2016.

Hanford L.C., Pinnock F., Hall G.B., Heinrichs R.W. Cortical thickness correlates of cognitive performance in cognitively-matched individuals with and without schizophrenia. Brain Cogn., 132: 129–137, 2019. doi:10.1016/j.bandc.2019.04.003.

Harris J.M., Yates S., Miller P., Best J.J., Johnstone E.C., Lawrie S.M. Gyrification in first-episode schizophrenia: a morphometric study. Biol. Psychiatry, 55: 141–147, 2004.

Haukvik U.K., Schaer M., Nesvåg R., McNeil T., Hartberg C.B., Jönsson E.G., Eliez S., Agartz I. Cortical folding in Broca's area relates to obstetric complications in schizophrenia patients and healthy controls. Psychol. Med., 42: 1329–1337, 2012.

Hendrickson T.J., Mueller B.A., Sowell E.R., Mattson S.N., Coles C.D., Kable J.A., Jones K.L., Boys C.J., Lee S., Lim K.O., Riley E.P., Wozniak J.R. Two-year cortical trajectories are abnormal in children and adolescents with prenatal alcohol exposure. Dev. Cogn. Neurosci., 30: 123–133, 2018.

Hilgetag C.C. and Barbas H. Developmental mechanics of the primate cerebral cortex. Anat. Embryol. (Berl), 210: 411–417, 2015.

Hutton C., De Vita E., Ashburner J., Deichmann R., Turner R. Voxel-based cortical thickness measurements in MRI. Neuroimage, 40: 1701–1710, 2008. https://doi:10.1016/j.neuroimage.2008.01.027.

Janssen J., Alemán-Gómez Y., Schnack H., Balaban E., Pina-Camacho L., Alfaro-Almagro F., Castro-Fornieles J., Otero S., Baeza I., Moreno D., Bargalló N., Parellada M., Arango C., Desco M. Cortical morphology of adolescents with bipolar disorder and with schizophrenia. Schizophr. Res., 158: 91–99, 2014.

Klein D., Rotarska-Jagiela A., Genc E., Sritharan S., Mohr H., Roux F., Han C.E., Kaiser M., Singer W., Uhlhaas P.J. Adolescent brain maturation and cortical folding: evidence for reductions in gyrification. PLoS One, 9: e84914, 2014.

Kong L., Herold C.J., Lässer M.M., Schmid L.A., Hirjak D., Thomann P.A., Essig M., Schröder J. Association of cortical thickness and neurological soft signs in patients with chronic schizophrenia and healthy controls. Neuropsychobiology, 71: 225–233, 2015.

Kubera K.M., Thomann P.A., Hirjak D., Barth A., Sambataro F., Vasic N., Wolf N.D., Frasch K., Wolf R.C. Cortical folding abnormalities in patients with schizophrenia who have persistent auditory verbal hallucinations. Eur Neuropsychopharmacol., 28: 297–306, 2018.

Kubota M., van Haren N.E., Haijma S.V., Schnack H.G., Cahn W., Hulshoff Pol H.E., Kahn R.S. Association of IQ changes and progressive brain changes in patients with schizophrenia. JAMA Psychiatry, 72: 803–812, 2015.

Kuperberg G.R., Broome M.R., McGuire P.K., David A.S., Eddy M., Ozawa F., Goff D., West W.C., Williams S.C., van der Kouwe A.J., Salat D.H., Dale A.M., Fischl B. Regionally localized thinning of the cerebral cortex in schizophrenia. Arch. Gen. Psychiatry, 60: 878–888, 2003.

Lawrie S.M. and Abukmeil S.S. Brain abnormality in schizophrenia. A systematic and quantitative review of volumetric magnetic resonance imaging studies. Br. J. Psychiatry, 172: 110–120, 1998.

Li G., Nie J., Wang L., Shi F., Lin W., Gilmore J.H., Shen D. Mapping region-specific longitudinal cortical surface expansion from birth to 2 years of age. Cereb. Cortex, 23: 2724–2733, 2013.

Li G., Wang L., Shi F., Lyall A.E., Ahn M., Peng Z., Zhu H., Lin W., Gilmore J.H., Shen D. Cortical thickness and surface area in neonates at high risk for schizophrenia. Brain Struct. Funct., 221: 447–461, 2016.

Liang S., Li Y., Zhang Z., Kong X., Wang Q., Deng W., Li X., Zhao L., Li M., Meng Y., Huang F., Ma X., Li X.M., Greenshaw A.J., Shao J., Li T. Classification of first-episode schizophrenia using multimodal brain features: A combined structural and diffusion imaging study. Schizophr. Bull., 45: 591–599, 2019.

Lin Y., Li M., Zhou Y., Deng W., Ma X., Wang Q., Guo W., Li Y., Jiang L., Hu X., Zhang N., Li T. Age-related reduction in cortical thickness in first-episode treatment-naïve patients with schizophrenia. Neurosci. Bull., 35: 688–696, 2009.

Mancini-Marïe A., Yoon U., Jiminez J., Fahim C., Potvin S., Grant J.A., Laverdure-Dupont D., Dubé A.A., Betrisey C., Rainville P., Evans A.C., Stip E., Mendrek A. Sex, age, symptoms and illness duration and their relation with gyrification index in schizophrenia. Clin. Schizophr. Relat. Psychoses, 12: 57–68, 2018.

Mensen A. and Khatami R. Advanced EEG analysis using threshold-free cluster-enhancement and non-parametric statistics. Neuroimage, 67: 111–118, 2013.

Nanda P., Tandon N., Mathew I.T., Giakoumatos C.I., Abhishekh H.A., Clementz B.A., Pearlson G.D., Sweeney J., Tamminga C.A., Keshavan M.S. Local gyrification index in probands with psychotic disorders and their first-degree relatives. Biol. Psychiatry, 76: 447–455, 2014.

Narr K.L., Bilder R.M., Kim S., Thompson P.M., Szeszko P., Robinson D., Luders E., Toga A.W. Abnormal gyral complexity in first-episode schizophrenia. Biol. Psychiatry, 55: 859–867, 2004.

Narr K.L., Bilder R.M., Toga A.W., Woods R.P., Rex D.E., Szeszko P.R., Robinson D., Sevy S., Gunduz-Bruce H., Wang Y.P., DeLuca H., Thompson P.M. Mapping cortical thickness and gray matter concentration in first episode schizophrenia. Cereb. Cortex, 15: 708–719, 2005a.

Narr K.L., Toga A.W., Szeszko P., Thompson P.M., Woods R.P., Robinson D., Sevy S., Wang Y., Schrock K., Bilder R.M. Cortical thinning in cingulate and occipital cortices in first episode schizophrenia. Biol. Psychiatry, 58: 32–40, 2005b.

Neilson E., Bois C., Clarke T.K., Hall L., Johnstone E.C., Owens D.G.C., Whalley H.C., McIntosh A.M., Lawrie S.M. Polygenic risk for schizophrenia, transition and cortical gyrification: a high-risk study. Psychol. Med., 48: 1532–1539, 2018.

Nelson M.D., Saykin A.J., Flashman L.A., Riordan H.J. Hippocampal volume reduction in schizophrenia as assessed by magnetic resonance imaging: a meta-analytic study. Arch. Gen. Psychiatry, 55: 433–440, 1998.

Nesvåg R., Schaer M., Haukvik U.K., Westlye L.T., Rimol L.M., Lange E.H., Hartberg C.B., Ottet M.C., Melle I., Andreassen O.A., Jönsson E.G., Agartz I., Eliez S. Reduced brain cortical folding in schizophrenia revealed in two independent samples. Schizophr. Res., 152: 333–338, 2014.

Oertel-Knöchel V., Knöchel C., Rotarska-Jagiela A., Reinke B., Prvulovic D., Haenschel C., Hampel H., Linden D.E. Association between psychotic symptoms and cortical thickness reduction across the schizophrenia spectrum. Cereb. Cortex, 23: 61–70, 2013.

Oguz I. and Sonka M. Robust cortical thickness measurement with LOGISMOS-B. Med. Image Comput. Assist. Interv., 17: 722–730, 2014.

Ohi K., Matsuda Y., Shimada T., Yasuyama T., Oshima K., Sawai K., Kihara H., Nitta Y., Okubo H., Uehara T., Kawasaki Y. Structural alterations of the superior temporal gyrus in schizophrenia: Detailed subregional differences. Eur. Psychiatry, 35: 25–31, 2016.

Palaniyappan L. and Liddle P.F. Diagnostic discontinuity in psychosis: a combined study of cortical gyrification and functional connectivity. Schizophr. Bull., 40: 675–684, 2014.

Palaniyappan L., Crow T., Hough M., Voets N.L., Liddle P.F., James S., Winmill L., James A.C. Gyrification of Broca’s region is anomalously lateralized at onset of schizophrenia in adolescence and regresses at 2-year follow-up. Schizophr. Res., 147: 39–45, 2013a.

Palaniyappan L., Marques T.R., Taylor H., Handley R., Mondelli V., Bonaccorso S., Giordano A., McQueen G., Di Forti M., Simmons A., David A.S., Pariante C.M., Murray R.M., Dazzan P. Cortical folding defects as markers of poor treatment response in first-episode psychosis. JAMA Psychiatry, 70: 1031–1040, 2013b.

Parellada M., Boada L., Fraguas D., Reig S., Castro-Fornieles J., Moreno D., Gonzalez-Pinto A., Otero S., Rapado-Castro M., Graell M., Baeza I., Arango C. Trait and state attributes of insight in first episodes of early-onset schizophrenia and other psychoses: a 2-year longitudinal study. Schizophr Bull., 37: 38–51, 2011.

Pina-Camacho L., Del Rey-Mejías Á., Janssen J., Bioque M., González-Pinto A., Arango C., Lobo A., Sarró S., Desco M., Sanjuan J., Lacalle-Aurioles M., Cuesta M.J., Saiz-Ruiz J., Bernardo M., Parellada M; PEPs Group. Age at first episode modulates diagnosis-related structural brain abnormalities in psychosis. Schizophr. Bull., 42: 344–357, 2016.

Raznahan A., Shaw P., Lalonde F., Stockman M., Wallace G.L., Greenstein D., Clasen L., Gogtay N., Giedd J.N. How does your cortex grow? J. Neurosci., 31: 7174–7177, 2011.

Reavis E.A., Lee J., Wynn J.K., Engel S.A., Jimenez A.M., Green M.F. Cortical thickness of functionally defined visual areas in schizophrenia and bipolar disorder. Cereb. Cortex., 27: 2984–2993, 2017.

Remer J., Croteau-Chonka E., Dean D.C.III, D'Arpino S., Dirks H., Whiley D., Deoni S.C.L. Quantifying cortical development in typically developing toddlers and young children, 1-6 years of age. Neuroimage, 153: 246–261, 2017.

Rimol L.M., Hartberg C.B., Nesvåg R., Fennema-Notestine C., Hagler D.J.Jr., Pung C.J., Jennings R.G., Haukvik U.K., Lange E., Nakstad P.H., Melle I., Andreassen O.A., Dale A.M., Agartz I. Cortical thickness and subcortical volumes in schizophrenia and bipolar disorder. Biol Psychiatry, 68: 41–50, 2010.

Rollins C.P.E., Garrison J.R., Simons J.S., Rowe J.B., O'Callaghan C., Murray G.K., Suckling J. Meta-analytic evidence for the plurality of mechanisms in transdiagnostic structural MRI studies of hallucination status. EClinicalMedicine, 8: 57–71, 2019.

Sasabayashi D., Takayanagi Y., Takahashi T., Koike S., Yamasue H., Katagiri N., Sakuma A., Obara C., Nakamura M., Furuichi A., Kido M., Nishikawa Y., Noguchi K., Matsumoto K., Mizuno M., Kasai K., Suzuki M. Increased occipital gyrification and development of psychotic disorders in individuals with an at-risk mental state: A multicenter study. Biol. Psychiatry, 82: 737–745, 2017.

Sasabayashi D., Takayanagi Y., Takahashi T., Nemoto K., Furuichi A., Kido M., Nishikawa Y., Nakamura M., Noguchi K., Suzuki M. Increased brain gyrification in the schizophrenia spectrum. Psychiatry Clin. Neurosci., 74: 70–76, 2020.

Schaer M., Cuadra M.B., Tamarit L., Lazeyras F., Eliez S., Thiran J-P. A Surface-based approach to quantify local cortical gyrification. IEEE Trans. Med. Imaging, 27: 161–170, 2008.

Schaer M., Cuadra M.B., Schmansky N., Fischl B., Thiran J.P., Eliez S. How to measure cortical folding from MR images: a step-by-step tutorial to compute local gyrification index. J. Vis. Exp., 59: e3417, 2012.

Schultz C.C., Koch K., Wagner G., Roebel M., Nenadic I., Gaser C., Schachtzabel C., Reichenbach J.R., Sauer H., Schlösser R.G. Increased parahippocampal and lingual gyrification in first-episode schizophrenia. Schizophr. Res., 123: 137–144, 2010.

Shaw P., Kabani N.J., Lerch J.P., Eckstrand K., Lenroot R., Gogtay N., Greenstein D., Clasen L., Evans A., Rapoport J.L., Giedd J.N., Wise S.P. Neurodevelopmental trajectories of the human cerebral cortex. J. Neurosci., 28: 3586–3594, 2008.

Sim K., DeWitt I., Ditman T., Zalesak M., Greenhouse I., Goff D., Weiss A.P., Heckers S. Hippocampal and parahippocampal volumes in schizophrenia: a structural MRI study. Schizophr. Bull., 32: 332–340, 2006.

Spalthoff R., Gaser C., Nenadić I. Altered gyrification in schizophrenia and its relation to other morphometric markers. Schizophr. Res., 202: 195–202, 2018.

Sprooten E., Papmeyer M., Smyth A.M., Vincenz D., Honold S., Conlon G.A., Moorhead T.W., Job D., Whalley H.C., Hall J., McIntosh A.M., Owens D.C., Johnstone E.C., Lawrie S.M. Cortical thickness in first-episode schizophrenia patients and individuals at high familial risk: a cross-sectional comparison. Schizophr. Res., 151: 259–264, 2013.

Steen R.G., Mull C., McClure R., Hamer R.M., Lieberman J.A. Brain volume in first-episode schizophrenia: systematic review and meta-analysis of magnetic resonance imaging studies. Br. J. Psychiatry, 188: 510-518, 2006.

Storvestre G.B., Valnes L.M., Jensen A., Nerland S., Tesli N., Hymer K.E., Rosaeg C., Server A., Ringen P.A., Jacobsen M., Andreassen O.A., Agartz I., Melle I., Haukvik U.K. A preliminary study of cortical morphology in schizophrenia patients with a history of violence. Psychiatry Res Neuroimaging, 288: 29–36, 2019.

Tadayon E., Pascual-Leone A., Santarnecchi E. Differential contribution of cortical thickness, surface area, and gyrification to fluid and crystallized intelligence. Cereb. Cortex, 2019.

Takayanagi Y., Sasabayashi D., Takahashi T., Furuichi A., Kido M., Nishikawa Y., Nakamura M., Noguchi K., Suzuki M. Reduced cortical thickness in schizophrenia and schizotypal disorder. Schizophr. Bull, 2019a.

Takayanagi Y., Sasabayashi D., Takahashi T., Komori Y., Furuichi A., Kido M., Nishikawa Y., Nakamura M., Noguchi K., Suzuki M. Altered brain gyrification in deficit and non-deficit schizophrenia. Psychol. Med., 49: 573–580, 2019b.

Tseng C.E., Chien Y.L., Liu C.M., Wang H.L., Hwu H.G., Tseng W.Y. Altered cortical structures and tract integrity of the mirror neuron system in association with symptoms of schizophrenia. Psychiatry Res., 231: 286–291, 2015.

Tustison N.J., Cook P.A., Klein A., Song G., Das S.R., Duda J.T., Kandel B.M., van Strien N., Stone J.R., Gee J.C., Avants B.B. Large-scale evaluation of ANTs and FreeSurfer cortical thickness measurements. Neuroimage, 99: 166–179, 2014.

van Haren N.E., Schnack H.G., Cahn W., van den Heuvel M.P., Lepage C., Collins L., Evans A.C., Hulshoff Pol H.E., Kahn R.S. Changes in cortical thickness during the course of illness in schizophrenia. Arch. Gen. Psychiatry, 68: 871-80, 2011.

Van Rheenen T.E., Cropley V., Zalesky A., Bousman C., Wells R., Bruggemann J., Sundram S., Weinberg D., Lenroot R.K., Pereira A., Shannon Weickert C., Weickert T.W., Pantelis C. Widespread volumetric reductions in schizophrenia and schizoaffective patients displaying compromised cognitive abilities. Schizophr. Bull., 44: 560–574, 2018.

Ventura J., Nuechterlein K.H., Subotnik K.L., Gutkind D., Gilbert E.A. Symptom dimension in recent-onset schizophrenia and mania: a principal components analysis of the 24-item Brief Psychiatric Rating Scale. Psychiatry Res., 97: 129–135, 2000.

Vogeley K., Schneider-Axmann T., Pfeiffer U., Tepest R., Bayer T.A., Bogerts B., Honer W.G., Falkai P. Disturbed gyrification of the prefrontal region in male schizophrenic patients: A morphometric postmortem study. Am. J. Psychiatry, 157: 34–39, 2000.

Walton E., Hibar D.P., van Erp T.G., Potkin S.G., Roiz-Santiañez R., Crespo-Facorro B., Suarez-Pinilla P., Van Haren N.E., de Zwarte S.M., Kahn R.S., Cahn W., Doan N.T., Jørgensen K.N., Gurholt T.P., Agartz I., Andreassen O.A., Westlye L.T., Melle I., Berg A.O., Mørch-Johnsen L., Faerden A., Flyckt L., Fatouros-Bergman H.; Karolinska Schizophrenia Project Consortium (KaSP), Jönsson E.G., Hashimoto R., Yamamori H., Fukunaga M., Preda A., De Rossi P., Piras F., Banaj N., Ciullo V., Spalletta G., Gur R.E., Gur R.C., Wolf D.H., Satterthwaite T.D., Beard L.M., Sommer I.E., Koops S., Gruber O., Richter A., Krämer B., Kelly S., Donohoe G., McDonald C., Cannon D.M., Corvin A., Gill M., Di Giorgio A., Bertolino A., Lawrie S., Nickson T., Whalley H.C., Neilson E., Calhoun V.D., Thompson P.M., Turner J.A., Ehrlich S. Positive symptoms associate with cortical thinning in the superior temporal gyrus via the ENIGMA Schizophrenia consortium. Acta Psychiatr. Scand., 135: 439–447, 2017.

Walton E., Hibar DP., van Erp T.G.M., Potkin S.G., Roiz-Santiañez R., Crespo-Facorro B., Suarez-Pinilla P., van Haren N.E.M., de Zwarte S.M.C., Kahn R.S., Cahn W., Doan N.T., Jørgensen K.N., Gurholt T.P., Agartz I., Andreassen O.A., Westlye L.T., Melle I., Berg A.O., Morch-Johnsen L., Færden A., Flyckt L., Fatouros-Bergman H; Karolinska Schizophrenia Project Consortium (KaSP), Jönsson E.G., Hashimoto R., Yamamori H., Fukunaga M., Jahanshad N., De Rossi P., Piras F., Banaj N., Spalletta G., Gur R.E., Gur R.C., Wolf D.H., Satterthwaite T.D., Beard L.M., Sommer I.E., Koops S. Gruber O., Richter A., Krämer B., Kelly S., Donohoe G., McDonald C., Cannon D.M., Corvin A., Gill M., Di Giorgio A., Bertolino A., Lawrie S., Nickson T., Whalley H.C., Neilson E., Calhoun V.D., Thompson P.M., Turner J.A., Ehrlich S. Prefrontal cortical thinning links to negative symptoms in schizophrenia via the ENIGMA consortium. Psychol. Med., 48: 82–94, 2018.

Wang Y., Deng Y., Fung G., Liu W.H., Wei X.H., Jiang X.Q., Lui S.S., Cheung E.F., Chan R.C.. Distinct structural neural patterns of trait physical and social anhedonia: evidence from cortical thickness, subcortical volumes and inter-regional correlations. Psychiatry Res., 224: 184–191, 2014.

Wannan C.M.J., Cropley V.L., Chakravarty M.M., Bousman C., Ganella E.P., Bruggemann J.M., Weickert T.W., Weickert C.S., Everall I., McGorry P., Velakoulis D., Wood S.J., Bartholomeusz C.F., Pantelis C., Zalesky A. Evidence for Network-Based Cortical Thickness Reductions in Schizophrenia. Am. J. Psychiatry, 176: 552–563, 2019.

Wheeler D.G. and Harper C.G. Localised reductions in gyrification in the posterior cingulate: schizophrenia and controls. Prog. Neuropsychopharmacol. Biol. Psychiatry, 31: 319–327, 2007.

Wheeler A.L., Wessa M., Szeszko P.R., Foussias G., Chakravarty M.M., Lerch J.P., DeRosse P., Remington G., Mulsant B.H., Linke J., Malhotra A.K., Voineskos A.N. Further neuroimaging evidence for the deficit subtype of schizophrenia: a cortical connectomics analysis. JAMA Psychiatry, 72: 446–455, 2015. https://doi:10.1001/jamapsychiatry.2014.3020.

Wisco J.J., Kuperberg G., Manoach D., Quinn B.T., Busa E., Fischl B., Heckers S., Sorensen A.G. Abnormal cortical folding patterns within Broca's area in schizophrenia: evidence from structural MRI. Schizophr. Res., 94: 317–327, 2007.

Wong T.Y., Radua J., Pomarol-Clotet E., Salvador R., Albajes-Eizagirre A., Solanes A., Canales-Rodriguez E.J., Guerrero-Pedraza A., Sarro S., Kircher T., Nenadic I., Krug A., Grotegerd D., Dannlowski U., Borgwardt S., Riecher-Rössler A., Schmidt A., Andreou C., Huber C.G., Turner J., Calhoun V., Jiang W., Clark S., Walton E., Spalletta G., Banaj N., Piras F., Ciullo V., Vecchio D., Lebedeva I., Tomyshev AS., Kaleda V., Klushnik T., Filho GB., Zanetti M.V., Serpa M.H., Penteado Rosa P.G., Hashimoto R., Fukunaga M., Richter A., Krämer B., Gruber O., Voineskos AN., Dickie E.W., Tomecek D., Skoch A., Spaniel F., Hoschl C., Bertolino A., Bonvino A., Di Giorgio A., Holleran L., Ciufolini S., Marques TR., Dazzan P., Murray R., Lamsma J., Cahn W., van Haren N., Díaz-Zuluaga AM., Pineda-Zapata J.A., Vargas C., López-Jaramillo C., van Erp T.G.M., Gur R.C., Nickl-Jockschat T. An overlapping pattern of cerebral cortical thinning is associated with both positive symptoms and aggression in schizophrenia via the ENIGMA consortium. Psychol. Med., 1–12, 2019.

Wood S.J., Pantelis C., Velakoulis D., Yücel M., Fornito A., McGorry P.D. Progressive changes in the development toward schizophrenia: studies in subjects at increased symptomatic risk. Schizophr. Bull., 34: 322–329, 2008.

Wright I.C., Rabe-Hesketh S., Woodruff P.W., David A.S., Murray R.M., Bullmore E.T. Meta-analysis of regional brain volumes in schizophrenia. Am. J. Psychiatry, 157: 16–25, 2000.

Yan J., Cui Y., Li Q., Tian L., Liu B., Jiang T., Zhang D., Yan H. Cortical thinning and flattening in schizophrenia and their unaffected parents. Neuropsychiatr. Dis. Treat., 15: 935–946, 2019.

Yi S.Y., Barnett B.R., Yu J.J. Preclinical neuroimaging of gene-environment interactions in psychiatric disease. Br. J. Radiol., 92: 20180885, 2019.

Zhang W., Deng W., Yao L., Xiao Y., Li F., Liu J., Sweeney J.A., Lui S., Gong Q. Brain structural abnormalities in a group of never-medicated patients with long-term schizophrenia. Am. J. Psychiatry, 172: 995–1003, 2015.

Zilles K., Armstrong E., Schleicher A., Kretschmann H.J. The human pattern of gyrification in the cerebral cortex. Anat. Embryol. (Berl), 179: 173–179, 1988.

Zilles K., Palomero-Gallagher N., Amunts K. Development of cortical folding during evolution and ontogeny. Trends Neurosci., 36: 275–284, 2013.

Zugman A., Pedrini M., Gadelha A., Kempton M.J., Noto C.S., Mansur R.B., Santoro M.L., Gama C.S., Bressan R.A., McGuire P., Jackowski A.P., Brietzke E. Serum brain-derived neurotrophic factor and cortical thickness are differently related in patients with schizophrenia and controls. Psychiatry Res., 234: 84–89, 2015.

Zuliani R., Delvecchio G., Bonivento C., Cattarinussi G., Perlini C., Bellani M., Marinelli V., Rossetti M.G., Lasalvia A., McIntosh A., Lawrie S.M., Balestrieri M., Ruggeri M., Brambilla P; PICOS Veneto Group. Increased gyrification in schizophrenia and non-affective first episode of psychosis. Schizophr. Res., 193: 269-275, 2018.



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