The prospective white matter: an atypical neurogenic niche in the developing cerebellum

Ketty Leto, Alice Bartolini, Ferdinando Rossi


Cerebellar GABAergic interneurons comprise heterogeneous phenotypes located at strategic levels of the local networks. Recent findings indicate that they all derive from a common population of multipotent progenitors whose fate choices are determined by instructive information provided by the PWM environment. Here we review about the atypical neurogenic strategy operated within such postnatal niche and we discuss possible instructive mechanisms governing interneuron specification and differentiation.


GABAergic interneurons, cerebellum, cell specification

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