Indole and trans–chalcone attenuate amyloid β plaque accumulation in male Wistar rat: in vivo effectiveness of two anti-amyloid scaffolds

Abstract

Alzheimer’s disease (AD) is an irreversible neurodegenarative condition in which abnormal  accumulation of amyloid plaques is observed, and for which no effective treatment still exist.  In recent years, many aromatic small molecules have been observed to have anti-amyloid effect, and may have the  potential to attenuate AD symptoms. The indole core and the flavonoid precursor trans-chalcone have been studied here as representative of these group of molecules. Formation of amyloid plaques has been induced in a rat model of AD, after what the two compounds were given to experimental groups. Shuttle box experiment and histological examination of brain amyloid plaques was then performed in order to test the effect of 28 days  treatment on  rats memory and brain tissue integrity. In conclusion, it was found that both compounds were effective in ameliorating the rats condition, and could be considered as interesting potential drug candidates.